Matt Priddis made his AFL debut for West Coast midway through the 2006 season, aged 21, recording 19 disposals and five tackles against Geelong. He played one further AFL game during the season, against Port Adelaide, spending the remainder of the season in the WAFL. Priddis averaged over 31 disposals per game at WAFL level, playing in a second premiership for Subiaco and winning the Sandover Medal with 58 votes at the end of the season, a competition record (since equalled by Kane Mitchell in 2012).

Having been upgraded to West Coast’s senior list for the 2007 season, Matt recorded 45 disposals, 30 handballs, 15 kicks, 5 marks and 3 tackles in round 14, 2008 against Hawthorn. His 30 handpasses was then the highest tally ever recorded (recorded since 1987), until Gary Ablett, Jr. broke the record the following season. During the 2013 season, Matt played his 150th game for West Coast, becoming a Life Member of the Club. At the end of the season, Matt was awarded West Coast’s best and fairest award, the newly named John Worsfold Medal. He had finished second in the award on two previous occasions, in 2010 and 2011.

After Darren Glass retired midway through the 2014 season, Matt was named acting Co-Captain of the club for the remainder of the season, along with four other players. He had been a member of the club’s leadership group since the 2009 season. He finished the home-and-away-season ranked first in disposals, second in contested possessions and third in tackles. Matt was awarded the Brownlow Medal as the AFL’s Best and Fairest Player at the end of the season. Polling 26 votes, Matt became the third West Coast player to win the award and the second person, after Haydn Bunton, Sr., to have won both a Brownlow Medal and a Sandover Medal. He also became the first player to win the award having begun his career on the rookie list. Matt’s best previous finish came in the 2011 Brownlow Medal count when, with 19 votes, he finished equal seventh.